5-LIPOXYGENASE GENE-EXPRESSION IN HL-60 CELLS DURING DIFFERENTIATION WITH DMSO

被引：8

作者：

PIECHELE, G ^{[1
]}

COLLI, S ^{[1
]}

TREMOLI, E ^{[1
]}

MAGGI, A ^{[1
]}

机构：

[1] UNIV MILAN, INST PHARMACOL SCI, VIA BALZARETTI 9, I-20133 MILAN, ITALY

来源：

PHARMACOLOGICAL RESEARCH | 1993年 / 27卷 / 01期

关键词：

HL-60; CELLS; HUMAN; 5-LIPOXYGENASE;

D O I：

10.1006/phrs.1993.1005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme. © 1993 Academic Press. All rights reserved.

引用

页码：53 / 60

页数：8

共 17 条

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