2 CASES SUGGESTING A ROLE FOR THE L-ARGININE NITRIC-OXIDE PATHWAY IN NEONATAL BLOOD-PRESSURE REGULATION

被引:33
作者
FAKLER, CR
KAFTAN, HA
NELIN, LD
机构
[1] MED COLL WISCONSIN,DEPT PEDIAT,MILWAUKEE,WI 53226
[2] CHILDRENS HOSP WISCONSIN,MILWAUKEE,WI 53201
关键词
ARGININOSUCCINATE LYASE DEFICIENCY; HYPERTENSION; HYPOTENSION; UREA CYCLE;
D O I
10.1111/j.1651-2227.1995.tb13673.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Endogenous nitric oxide produced from L-arginine is a potent vasodilator that may be involved in blood pressure regulation. A male infant with argininosuccinate lyase deficiency, who could not synthesize L-arginine, was hypertensive prior to L-arginine replacement. The infusion of L-arginine resulted in a decrease in blood pressure. A three-fold increase in the dose of L-arginine further decreased blood pressure. On discontinuing the infusion of L-arginine, the patient's blood pressure increased. A female infant undergoing an L-arginine challenge test had a decrease in blood pressure during L-arginine infusion which resolved when the L-arginine infusion was discontinued. These two cases suggest that nitric oxide production from L-arginine may play a role in the normal regulation of systemic blood pressure.
引用
收藏
页码:460 / 462
页数:3
相关论文
共 8 条
[1]  
Castillo L., 1993, Pediatric Research, V33, p20A
[2]  
ELLIOT SJ, 1990, FETAL NEONATAL CARDI, P492
[3]   N-OMEGA-NITRO-L-ARGININE ATTENUATES ENDOTHELIUM-DEPENDENT PULMONARY VASODILATION IN LAMBS [J].
FINEMAN, JR ;
HEYMANN, MA ;
SOIFER, SJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (04) :H1299-H1306
[4]   L-ARGININE INFUSION INDUCES HYPOTENSION AND DIURESIS NATRIURESIS WITH CONCOMITANT INCREASED URINARY-EXCRETION OF NITRITE NITRATE AND CYCLIC-GMP IN HUMANS [J].
KANNO, K ;
HIRATA, Y ;
EMORI, T ;
OHTA, K ;
EGUCHI, S ;
IMAI, T ;
MARUMO, F .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1992, 19 (09) :619-625
[5]  
NAKAKI T, 1991, LANCET, V337, P683
[6]  
NATHAN C, 1993, FASEB J, V6, P3051
[7]   EFFECT OF NITRIC-OXIDE SYNTHASE INHIBITORS ON HYPOTENSION IN PATIENTS WITH SEPTIC SHOCK [J].
PETROS, A ;
BENNETT, D ;
VALLANCE, P .
LANCET, 1991, 338 (8782-3) :1557-1558
[8]   PLASMA NITRIC-OXIDE LEVELS IN NEWBORN-INFANTS WITH SEPSIS [J].
SHI, YA ;
LI, HQ ;
SHEN, CK ;
WANG, JH ;
QIN, SW ;
LIU, R ;
PAN, J .
JOURNAL OF PEDIATRICS, 1993, 123 (03) :435-438