TRICYCLIC HETEROAROMATIC SYSTEMS - SYNTHESIS AND A(1) AND A(2A) ADENOSINE BINDING ACTIVITIES OF SOME 1-ARYL-1,4-DIHYDRO-3-METHYL[1]BENZOPYRANO[2,3-C]PYRAZOL-4-ONES, 1-ARYL-4,9-DIHYDRO-3-METHYL-1H-PYRAZOLO[3,4-B]QUINOLIN-4-ONES, AND 1-ARYL-1H-IMIDAZO[4,5-B]QUINOXALINES

被引：62

作者：

CATARZI, D

CECCHI, L

COLOTTA, V

FILACCHIONI, G

MARTINI, C

TACCHI, P

LUCACCHINI, A

机构：

[1] UNIV FLORENCE,DIPARTIMENTO SCI FARMACEUT,I-50121 FLORENCE,ITALY

[2] UNIV PISA,IST POLICATTEDRA DISCIPLINE BIOL,I-56100 PISA,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 08期

关键词：

D O I：

10.1021/jm00008a011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The syntheses and A(1) and A(2a) adenosine binding activities of some new 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c]pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]-quinolin-4-ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines are reported. Some compounds show A(1) adenosine receptor affinity and selectivity. Structure-activity relationships on these new classes of adenosine receptor ligands are defined.

引用

页码：1330 / 1336

页数：7

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