PERITONEAL FIBRINOLYTIC-ACTIVITY AND INTRAABDOMINAL ADHESIONS

被引：197

作者：

VIPOND, MN ^{[1
]}

WHAWELL, SA ^{[1
]}

THOMPSON, JN ^{[1
]}

DUDLEY, HAF ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,DEPT SURG,LONDON W12 0HS,ENGLAND

来源：

LANCET | 1990年 / 335卷 / 8698期

关键词：

D O I：

10.1016/0140-6736(90)91125-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms leading to reduction of peritoneal fibrinolytic activity in conditions that are associated with the formation of intra-abdominal adhesions were studied. Tissue plasminogen activator was found, by antibody inhibition techniques, to be the activator of fibrinolysis in homogenates of control peritoneum (n=6). Homogenates of control (n=10) and inflamed peritoneum (n=10) were analysed. Plasminogen activating activity was much lower in inflamed peritoneum (median 0·07 IU/cm2) than in control tissue (median 12·0 IU/cm2) (p<0·001). Levels of tissue plasminogen activator and α2-antiplasmin were similar in both control and inflamed tissue. Plasminogen activator inhibitor-1, not detectable in control peritoneum, was present in inflamed tissue and might be the reason for the reduction in functional fibrinolytic activity. © 1990.

引用

页码：1120 / 1122

页数：3

共 12 条

[1]

ALCHALABI HA, 1987, INT J FERTIL, V32, P332

[2]

BEVAN PG, 1984, ANN ROY COLL SURG, V66, P164

[3]

DOODY KJ, 1989, FERTIL STERIL, V51, P509

[4] HEALING OF PERITONEUM UNDER NORMAL AND PATHOLOGICAL CONDITIONS [J].

ELLIS, H ;

HARRISON, W ;

HUGH, TB .

BRITISH JOURNAL OF SURGERY, 1965, 52 (06) :471-&

[5]

HANSS M, 1987, J LAB CLIN MED, V109, P97

[6]

HAU T, 1979, SURG GYNECOL OBSTET, V148, P415

[7] INTRA-ABDOMINAL ADHESIONS AND THEIR PREVENTION BY TOPICAL TISSUE PLASMINOGEN-ACTIVATOR [J].

MENZIES, D ;

ELLIS, H .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1989, 82 (09) :534-535

[8]

MYHREJENSEN O, 1969, ARCH PATHOL, V88, P623

[9]

RAFTERY AT, 1979, J ANAT, V129, P659

[10]

RANBY M, 1988, ENZYME, V40, P130

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