PROSPECTIVE TRIAL OF INTRAOPERATIVE MITOMYCIN-C IN THE TREATMENT OF PRIMARY PTERYGIUM

被引：78

作者：

CANOPARRA, J ^{[1
]}

DIAZLLOPIS, M ^{[1
]}

MALDONADO, MJ ^{[1
]}

VILA, E ^{[1
]}

MENEZO, JL ^{[1
]}

机构：

[1] LA FE UNIV HOSP,DEPT OPHTHALMOL,VALENCIA,SPAIN

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1995年 / 79卷 / 05期

关键词：

D O I：

10.1136/bjo.79.5.439

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Aims-A prospective, randomised, double blind, placebo controlled study of intraoperative mitomycin C as adjunctive treatment of primary pterygium was conducted. Methods-A total of 66 eyes of 54 patients with primary pterygium were treated with excision, with or without a single intraoperative application of mitomycin C (0.1 mg/ml for 5 minutes) to evaluate the efficacy and toxicity of this adjunctive treatment. The mean follow up was 14.1 months (range 12-23 months). Results-Of the 36 eyes that underwent simple excision, 14 (38.8%) exhibited recurrences whereas only one of 30 eyes (3.33%) treated with excision and intraoperative application of mitomycin C had recurrence (p=0.0006). Neither serious ocular complications nor systemic toxicity were noted in the mitomycin C treated group. Conclusion-Intraoperative mitomycin C appears to be an effective and safe adjunctive treatment of primary pterygium.

引用

页码：439 / 441

页数：3

共 24 条

[1] HISTOLOGY OF PTERYGIUM - AN ELECTRON-MICROSCOPIC STUDY [J].