COMPARATIVE-ANALYSIS OF THE GENETIC ASSOCIATIONS OF HLA-DRS AND TUMOR-NECROSIS-FACTOR-ALPHA WITH HUMAN IDDM

被引：47

作者：

COX, A ^{[1
]}

GONZALEZ, AM ^{[1
]}

WILSON, AG ^{[1
]}

WILSON, RM ^{[1
]}

WARD, JD ^{[1
]}

ARTLETT, CM ^{[1
]}

WELSH, K ^{[1
]}

DUFF, GW ^{[1
]}

机构：

[1] CHURCHILL HOSP,CTR TRANSPLANT,OXFORD OX3 7LJ,ENGLAND

来源：

DIABETOLOGIA | 1994年 / 37卷 / 05期

关键词：

IDDM; MHC; TUMOR NECROSIS FACTOR ALPHA; POLYMORPHISM;

D O I：

10.1007/s001250050138

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-dependent diabetes mellitus (IDDM) is associated with class II molecules of the MHC on chromosome 6, in particular HLA-DR and -DQ alleles, but a pathogenic role for TNF-alpha in the class III region of the MHC has also been implied. We therefore tested whether there was any independent association between a biallelic TNF polymorphism and IDDM. The TNF2 allele was present in 61 of 114 (54%) IDDM patients compared to 101 of 253 (40%) control subjects (odds ratio 1.73; p < 0.02). Stratification analysis in individuals matched for HLA-DR3 revealed, however, that this association was not independent of HLA-DR3 and is most likely to be a result of linkage disequilibrium between these alleles.

引用

页码：500 / 503

页数：4

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