DIVALENT METAL-CATIONS UPON COORDINATION TO THE N7 OF PURINES DIFFERENTIALLY STABILIZE THE PYPUPU DNA TRIPLEX DUE TO UNEQUAL HOOGSTEEN-TYPE HYDROGEN-BOND ENHANCEMENT

被引：79

作者：

POTAMAN, VN

SOYFER, VN

机构：

[1] GEORGE MASON UNIV, DEPT BIOL, FAIRFAX, VA 22030 USA

[2] RUSSIAN ACAD SCI, INST MOLEC GENET, MOSCOW 123182, RUSSIA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1994年 / 11卷 / 05期

关键词：

D O I：

10.1080/07391102.1994.10508050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The PyPuPu triplexes consisting of CG*G triads are stabilized by alkaline earth cations (Ca2+, Mg2+) and transition metal cations (Mn2+, Co2+, Ni2+, Zn2+, Cd2+), while similar triplexes including TA*A triads are stabilized only by transition metal cations. We hypothesize that such a differential tripler stabilization by divalent metal cations can be the consequence of their coordination to the N7 of the third strand purines with concomitant polarization effects on the bases resulting in unequal Hoogsteen-type hydrogen bond enhancement.

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页码：1035 / 1040

页数：6

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