PRIMACY AND RECENCY EFFECTS IN RHESUS-MONKEYS (MACACA-MULATTA) USING A SERIAL PROBE RECOGNITION TASK .1. EFFECTS OF DIAZEPAM

被引:21
作者
CASTRO, CA [1 ]
机构
[1] USA,MED RES INST CHEM DEF,DIV DRUG ASSESMENT,ABERDEEN,MD 21010
关键词
RHESUS MONKEY; DIAZEPAM; SERIAL PROBE RECOGNITION TASK;
D O I
10.1007/BF02245858
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this study, we evaluated the effects of diazepam (0.2, 0.8, 1.6 and 3.2 mg/kg; IM) on the primacy and recency memory effects in four rhesus monkeys trained on a six-item serial probe recognition (SPR) task. Only the highest dose of diazepam (3.2 mg/kg) consistently affected the shape of the monkeys' serial position curves. Accuracy on the probe trials was disrupted for list items which occurred in the middle portion and recency memory component of the serial position curve, without affecting the primacy component. Diazepam, however, also produced several nonspecific effects on SPR performance. Both the 1.6 and 3.2 mg/kg diazepam doses disrupted accuracy on the non-matching probe trials, and the 3.2 mg/kg dose caused an increase in response latencies which were unrelated to any one component of the serial position curve. This is the first demonstration in nonhuman primates showing that the primacy and recency memory effects can be differentiated on the basis of diazepam dose.
引用
收藏
页码:421 / 427
页数:7
相关论文
共 36 条
[1]   EFFECTS OF PHENCYCLIDINE, SECOBARBITAL AND DIAZEPAM ON EYE TRACKING IN RHESUS-MONKEYS [J].
ANDO, K ;
JOHANSON, CE ;
LEVY, DL ;
YASILLO, NJ ;
HOLZMAN, PS ;
SCHUSTER, CR .
PSYCHOPHARMACOLOGY, 1983, 81 (04) :295-300
[2]  
BLOCK RI, 1994, PHARM BIOCH BEHAV, V20, P233
[3]   BEHAVIORAL EFFICACY OF DIAZEPAM AGAINST NERVE AGENT EXPOSURE IN RHESUS-MONKEYS [J].
CASTRO, CA ;
LARSEN, T ;
FINGER, AV ;
SOLANA, RP ;
MCMASTER, SB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 41 (01) :159-164
[4]   BEHAVIORAL DECREMENTS PERSIST IN RHESUS-MONKEYS TRAINED ON A SERIAL PROBE RECOGNITION TASK DESPITE PROTECTION AGAINST SOMAN LETHALITY BY BUTYRYLCHOLINESTERASE [J].
CASTRO, CA ;
GRESHAM, VC ;
FINGER, AV ;
MAXWELL, DM ;
SOLANA, RP ;
LENZ, DE ;
BROOMFIELD, CA .
NEUROTOXICOLOGY AND TERATOLOGY, 1994, 16 (02) :145-148
[5]   PRIMACY AND RECENCY EFFECTS IN NONHUMAN-PRIMATES [J].
CASTRO, CA ;
LARSEN, T .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1992, 18 (04) :335-340
[6]  
CURRAN HV, 1991, PSYCHOPHARMACOLOGY, V105, P1
[7]   A CONVEYOR BELT TASK FOR ASSESSING VISUO-MOTOR COORDINATION IN THE MARMOSET (CALLITHRIX-JACCHUS) - EFFECTS OF DIAZEPAM, CHLORPROMAZINE, PENTOBARBITAL AND D-AMPHETAMINE [J].
DMELLO, GD ;
DUFFY, EAM ;
MILES, SS .
PSYCHOPHARMACOLOGY, 1985, 86 (1-2) :125-131
[8]   PROBE VERSUS FREE-RECALL [J].
DONG, T .
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR, 1972, 11 (05) :654-&
[9]   MEMORY PROCESSES AND SERIAL POSITION CURVE [J].
ELLIS, NR ;
HOPE, R .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1968, 77 (04) :613-&
[10]  
FFARACS AB, 1983, NZ MED J, V96, P210