CHANGES IN HEPATIC FOLYLPOLYGLUTAMATE PATTERN IN PHENOBARBITONE-TREATED RATS

被引：4

作者：

BOVINA, C ^{[1
]}

FORMIGGINI, G ^{[1
]}

BATTINO, M ^{[1
]}

SASSI, S ^{[1
]}

MARCHETTI, M ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT BIOCHEM,VIA IRNERIO 48,I-40126 BOLOGNA,ITALY

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 12期

关键词：

D O I：

10.1016/0006-2952(90)90600-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Folate deficiency is a common unpleasant secondary effect of anticonvulsant therapy. In order to contribute to the knowledge of biochemical mechanisms leading to this condition, the effects of two i.p. high doses of phenobarbitone administered to the rat (acute treatment) on the distribution of hepatic folate derivatives have been studied. A significant decrease of unsubstituted tetrahydro- and dihydropteroylpentaglutamates and 5,10-methylenetetrahydropentaglutamates was observed. The hypothesis that a lower availability of NADPH, which is utilized for hydroxylation reactions in phenobarbitone metabolism, may limit folate reduction is proposed. © 1990.

引用

页码：1847 / 1851

页数：5

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