MULTIPLE CLONAL CHROMOSOME-ABNORMALITIES IN PEYRONIES DISEASE

被引：31

作者：

GUERNERI, S

STIOUI, S

MANTOVANI, F

AUSTONI, E

SIMONI, G

机构：

[1] UNIV MILAN,UROL CLIN,I-20122 MILAN,ITALY

[2] UNIV MILAN,OSTET & GINECOL CLIN,I-20122 MILAN,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 52卷 / 02期

关键词：

D O I：

10.1016/0165-4608(91)90461-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.

引用

页码：181 / 185

页数：5

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