STUDIES ON THE SYNTHESIS OF C-2 SUBSTITUTED CEPHALOSPORIN SULFONES - THE UNEXPECTED REACTIVITY OF THE C-2 CARBON

被引:5
作者
BOTTA, M [1 ]
CRUCIANELLI, M [1 ]
SALADINO, R [1 ]
NICOLETTI, R [1 ]
机构
[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO CHEM,I-00185 ROME,ITALY
关键词
D O I
10.3987/COM-92-6025
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An interesting route for the synthesis of C-2 substituted cephalosporin sulfones (8) has been described along with an unexpected reactivity on the C-2 carbon of C-2 substituted cephalosporin sulfoxides and sulfones.
引用
收藏
页码:1375 / 1384
页数:10
相关论文
共 8 条
[1]  
ALPEGIANI M, COMMUNICATION
[2]   CHEMISTRY OF DIHYDROTHIAZINE RING MOIETY OF CEPHALOSPORINS .1. REGIOSPECIFICITY AND STEREOSELECTIVITY IN BROMINE ADDITION TO 2-CEPHEM DERIVATIVES - NEW ROUTE TO 2-METHOXY CEPHALOSPORINS [J].
BALSAMO, A ;
CROTTI, P ;
MACCHIA, B ;
MACCHIA, F ;
NANNINI, G ;
DRADI, E ;
FORGIONE, A .
JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (12) :2150-2153
[3]   NUCLEOPHILIC DISPLACEMENTS ALPHA TO SULFONYL GROUPINGS [J].
BORDWELL, FG ;
JARVIS, BB .
JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (03) :1182-&
[4]  
DOHERTY JB, 1986, NATURE, V322, P192, DOI 10.1038/322192a0
[5]  
GHUYSEN JM, 1976, BACTERIAL D D CARBOX, P1125
[6]   INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY C-2 SUBSTITUTED CEPHALOSPORIN SULFONES [J].
HAGMANN, WK ;
OGRADY, LA ;
ASHE, BM ;
DAHLGREN, ME ;
WESTON, H ;
MAYCOCK, AL ;
KNIGHT, WB ;
DOHERTY, JB .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1989, 24 (06) :599-604
[7]   CHEMISTRY OF CEPHALOSPORIN ANTIBIOTICS .18. SYNTHESIS OF 7-ACYL-3-METHYL-2-CEPHEM-4-CARBOXYLIC ACID ESTERS [J].
MURPHY, CF ;
KOEHLER, RE .
JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (07) :2429-&
[8]  
SPRY DO, 1972, TETRAHEDRON LETT, P3717