IMMUNOHISTOCHEMICAL DETECTION OF PROLIFERATING TUMOR-CELLS IN CERVICAL-CANCER USING MONOCLONAL-ANTIBODY KI-67

Monoclonal antibody Ki-67 identifies cells in G1, S, G2, and M phases of the cell cycle. In this cytokinetic study, Ki-67 was used to characterize tumor cells in human cervical cancer specimen. This immunohistochemical study showed that Ki-67 staining gave a brown nuclear reactivity dispersed heterogeneously in a tumor cell population and correlated well with the mitotic activities of tumor cells. The finding suggested that Ki-67 staining provides an easily countable index for the study of proliferating cell populations in cervical cancer.