KINETIC RESOLUTION OF CHIRAL HYDROPEROXIDES VIA SHARPLESS EPOXIDATION

被引：13

作者：

HOFT, E

HAMANN, HJ

KUNATH, A

机构：

[1] Centre of Selective Organic Synthesis, Berlin, Adlershof

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1994年 / 336卷 / 06期

关键词：

D O I：

10.1002/prac.19943360611

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The kinetic resolution of tertiary hydroperoxides via catalytic Sharpless epoxidation with various allylic alcohols has been investigated. By using 1-cyclohexyl-1-phenylethyl hydroperoxide an enantiomeric excess (e.e.) of up to 29 % of the resolved hydroperoxide has been observed at a consumption of the racemic hydroperoxide of nearly 50 %. The e.e. can be increased, however, only by raising the hydroperoxide consumption.

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页码：534 / 537

页数：4

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