INTERLEUKIN-1-BETA INDUCES THE PRODUCTION OF AN L-ARGININE-DERIVED RELAXING FACTOR FROM CULTURED SMOOTH-MUSCLE CELLS FROM RAT AORTA

被引:118
作者
SCHINI, VB
JUNQUERO, DC
SCOTTBURDEN, T
VANHOUTTE, PM
机构
[1] Center for Experimental Therapeutics, Baylor College of Medicine, Houston, TX 77030, One Baylor Plaza
关键词
D O I
10.1016/0006-291X(91)90897-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of interleukin-1 β on the production of non-prostanoid vasoactive factors by cultured rat aortic smooth muscle cells was investigated. Under bioassay conditions, the perfusate from a column of confluent cells grown on beads and treated with interleukin-1 β (1 ng/ml for 18 to 24 hr) abolished the contraction of a canine coronary ring without endothelium contracted by phenylephrine (1 μM), while the perfusate from control cells had no effect. The relaxing activity of the perfusate was observed when transit times were increased from 1 sec to 5 min. Nitro L-arginine (100 μM) reversed the relaxations and L-arginine stereoselectively restored the relaxations. Interleukin-1 β (1 ng/ml) evoked a time-dependent accumulation of cyclic GMP but not cyclic AMP in cultured smooth muscle cells. The transfer of fresh or stored (-70°C) conditioned culture medium from interleukin-1 β-treated cells but not from control cells, to cultured smooth muscle cells stimulated the production of cyclic GMP. These observations demonstrate that interleukin-1 β induces the production of transferable factor which relaxes vascular smooth muscle and stimulates the production of cyclic GMP. © 1991.
引用
收藏
页码:114 / 121
页数:8
相关论文
共 23 条
  • [1] INTERLEUKIN-1 INHIBITS CONTRACTION OF VASCULAR SMOOTH-MUSCLE
    BEASLEY, D
    COHEN, RA
    LEVINSKY, NG
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (01) : 331 - 335
  • [2] ENDOTOXIN-INDUCED IMPAIRMENT OF VASCULAR SMOOTH-MUSCLE CONTRACTIONS ELICITED BY DIFFERENT MECHANISMS
    BIGAUD, M
    JULOUSCHAEFFER, G
    PARRATT, JR
    STOCLET, JC
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 190 (1-2) : 185 - 192
  • [3] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME
    BREDT, DS
    SNYDER, SH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 682 - 685
  • [4] INDUCTION OF NITRIC-OXIDE SYNTHASE BY CYTOKINES IN VASCULAR SMOOTH-MUSCLE CELLS
    BUSSE, R
    MULSCH, A
    [J]. FEBS LETTERS, 1990, 275 (1-2) : 87 - 90
  • [5] INCUBATION WITH ENDOTOXIN ACTIVATES THE L-ARGININE PATHWAY IN VASCULAR TISSUE
    FLEMING, I
    GRAY, GA
    JULOUSCHAEFFER, G
    PARRATT, JR
    STOCLET, JC
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 171 (02) : 562 - 568
  • [6] SPECIES-DEPENDENT DIFFERENCES IN THE NATURE OF ENDOTHELIUM-DERIVED VASCULAR RELAXING FACTOR
    FORSTERMANN, U
    TROGISCH, G
    BUSSE, R
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (03) : 639 - 643
  • [7] THE NATURE OF ENDOTHELIUM-DERIVED VASCULAR RELAXANT FACTOR
    GRIFFITH, TM
    EDWARDS, DH
    LEWIS, MJ
    NEWBY, AC
    HENDERSON, AH
    [J]. NATURE, 1984, 308 (5960) : 645 - 647
  • [8] GRUETTER CA, 1979, J CYCLIC NUCL PROT, V5, P211
  • [9] NITRIC-OXIDE - A CYTO-TOXIC ACTIVATED MACROPHAGE EFFECTOR MOLECULE
    HIBBS, JB
    TAINTOR, RR
    VAVRIN, Z
    RACHLIN, EM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 157 (01) : 87 - 94
  • [10] LOSS OF VASCULAR RESPONSIVENESS INDUCED BY ENDOTOXIN INVOLVES L-ARGININE PATHWAY
    JULOUSCHAEFFER, G
    GRAY, GA
    FLEMING, I
    SCHOTT, C
    PARRATT, JR
    STOCLET, JC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (04): : H1038 - H1043