ANDROGEN METABOLISM IN THE BRAIN

被引：59

作者：

MARTINI, L ^{[1
]}

MELCANGI, RC ^{[1
]}

机构：

[1] UNIV MILAN, IST ENDOCRINOL, VIA BALZARETTI 9, I-20133 MILAN, ITALY

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1991年 / 39卷 / 5B期

关键词：

D O I：

10.1016/0960-0760(91)90031-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paper summarizes the most recent views on androgen metabolism in the brain. In particular it will be shown that: (1) the enzyme 5-alpha-reductase is particularly concentrated in the white matter; (2) 5-alpha-reductase is also present in the myelin; 5-alpha-reductase is present in higher concentrations in neurons (isolated or cultured) that in glial cells (astrocytes and oligodendrocytes); (4) only neurons possess the capability of aromatizing androgens to estrogens; and (5) a possible role of steroid metabolism in the control of the process of myelinogenesis is suggested.

引用

页码：819 / 828

页数：10

共 79 条

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