SYNTHESIS OF ENANTIOMERICALLY PURE (2'R,5'S)-(-)-1-[2-(HYDROXYMETHYL)OXATHIOLAN-5-YL]CYTOSINE AS A POTENT ANTIVIRAL AGENT AGAINST HEPATITIS-B VIRUS (HBV) AND HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)

被引：173

作者：

BEACH, JW

JEONG, LS

ALVES, AJ

POHL, D

KIM, HO

CHANG, CN

DOONG, SL

SCHINAZI, RF

CHENG, YC

CHU, CK

机构：

[1] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM,ATHENS,GA 30602

[2] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

[3] EMORY UNIV,VET ADM MED CTR,SCH MED,ATLANTA,GA 30033

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 08期

关键词：

D O I：

10.1021/jo00034a006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the enantiomerically pure 2'R,5'S-(-) form of BCH-189 from L-gulose has been accomplished, and this isomer has been found to exhibit the most potent anti-HIV and anti-HBV activities among the four possible isomers. This is the first example of an "L-like" nucleoside which is more potent than its "D-like" isomer.

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页码：2217 / 2219

页数：3

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