TRIVALENT LANTHANIDE IONS DO NOT CLEAVE RNA IN DNA-RNA HYBRIDS

被引：47

作者：

KOLASA, KA ^{[1
]}

MORROW, JR ^{[1
]}

SHARMA, AP ^{[1
]}

机构：

[1] SUNY Buffalo, DEPT CHEM, BUFFALO, NY 14214 USA

来源：

INORGANIC CHEMISTRY | 1993年 / 32卷 / 19期

关键词：

D O I：

10.1021/ic00071a002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lanthanide(III) complexes rapidly catalyze cleavage of single-stranded RNA. RNA cleavage by lanthanide complexes is, however, dependent on RNA structure. A DNA-RNA hybrid formed by annealing a complementary oligodeoxynucleotide to t-RNA(phe) is found to be inert to cleavage by a europium(III) hexadentate Schiff base complex and by Eu(CO2CH3)3. Because DNA-RNA hybrids are important structures in antisense oligonucleotide strategies, these results may influence the design of antisense oligonucleotides with attached metal complex cleaving agents.

引用

页码：3983 / 3984

页数：2

共 30 条

[1] ON THE MECHANISM OF CATALYSIS BY RIBONUCLEASE - CLEAVAGE AND ISOMERIZATION OF THE DINUCLEOTIDE UPU CATALYZED BY IMIDAZOLE BUFFERS
ANSLYN, E
BRESLOW, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) : 4473 - 4482
[2] SYNTHESES, X-RAY STRUCTURES, AND PROPERTIES OF COMPLEXES OF MACROCYCLIC HEXAIMINES WITH LANTHANIDE NITRATES
ARIF, AM
BACKERDIRKS, JDJ
GRAY, CJ
HART, FA
HURSTHOUSE, MB
[J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1987, (07): : 1665 - 1673
[3] BASIC POLYPEPTIDES ACCELERATE THE HYDROLYSIS OF RIBONUCLEIC-ACIDS
BARBIER, B
BRACK, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (20) : 6880 - 6882
[4] ON THE MECHANISM OF ACTION OF RIBONUCLEASES - DINUCLEOTIDE CLEAVAGE CATALYZED BY IMIDAZOLE AND ZN-2+
BRESLOW, R
HUANG, DL
ANSLYN, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) : 1746 - 1750
[5] A NEGATIVE CATALYTIC TERM REQUIRES A COMMON INTERMEDIATE IN THE IMIDAZOLE BUFFER CATALYZED CLEAVAGE AND REARRANGEMENT OF RIBODINUCLEOTIDES
BRESLOW, R
HUANG, DL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (26) : 9621 - 9623
[6] PB(II)-CATALYSED CLEAVAGE OF THE SUGAR-PHOSPHATE BACKBONE OF YEAST TRANSFER RNAPHE - IMPLICATIONS FOR LEAD TOXICITY AND SELF-SPLICING RNA
BROWN, RS
HINGERTY, BE
DEWAN, JC
KLUG, A
[J]. NATURE, 1983, 303 (5917) : 543 - 546
[7] CRYSTALLOGRAPHIC AND BIOCHEMICAL INVESTIGATION OF THE LEAD(II)-CATALYZED HYDROLYSIS OF YEAST PHENYLALANINE TRANSFER-RNA
BROWN, RS
DEWAN, JC
KLUG, A
[J]. BIOCHEMISTRY, 1985, 24 (18) : 4785 - 4801
[8] PROBING THE ENVIRONMENT OF LANTHANIDE BINDING-SITES IN YEAST TRANSFER RNAPHE BY SPECIFIC METAL-ION-PROMOTED CLEAVAGES
CIESIOLKA, J
MARCINIEC, T
KRZYZOSIAK, WJ
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1989, 182 (02): : 445 - 450
[9] HEXAAZA MACROCYCLIC COMPLEXES OF THE LANTHANIDES
DECOLA, L
SMAILES, DL
VALLARINO, LM
[J]. INORGANIC CHEMISTRY, 1986, 25 (10) : 1729 - 1732
[10] INTERACTION OF METAL IONS WITH NUCLEIC ACIDS AND RELATED COMPOUNDS .16. SPECIFIC CLEAVAGE EFFECTS IN DEPOLYMERIZATION OF RIBONUCLEIC ACIDS BY ZINC(II) IONS
EICHHORN, GL
TARIEN, E
BUTZOW, JJ
[J]. BIOCHEMISTRY, 1971, 10 (11) : 2014 - &

← 1 2 3 →