PHARMACOLOGICAL SCREENING OF THE METHANOL AND DICHLOROMETHANOL EXTRACTS OF GENISTA PATENS

被引：4

作者：

BELLO, R ^{[1
]}

BARRACHINA, MD ^{[1
]}

MARTINEZCUESTA, MA ^{[1
]}

ESPLUGUES, J ^{[1
]}

YUFERA, EP ^{[1
]}

机构：

[1] UNIV POLITECN VALENCIA,CSIC,INST TECNOL QUIM,E-46071 VALENCIA,SPAIN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 07期

关键词：

GENISTA PATENS DC; CNS ACTIVITY; ANALGESIC ANTIINFLAMMATORY ACTIVITY; BLOOD PRESSURE; SMOOTH MUSCLE; PLANT EXTRACT;

D O I：

10.1002/ptr.2650090706

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pharmacological effects of the dichloromethanol and methanol extracts obtained from leaves and stems of Genista patens DC were analysed in in vitro and in vivo models. Both extracts showed low acute toxicity (LD(50) > 3 g/kg), CNS depressor and antiinflammatory activity, and similar analgesic effect in models of chemical and thermal stimulation. Furthermore, the dichloromethanol extract (1-20 mg/kg) induced a pronounced dose-dependent decrease on blood pressure. On isolated organs, the dichloromethanol extract (1, 10, 100 mu g/mL) shifted the concentration-effect curve to the right for ACh and reduced the E(max) induced by histamine without modifying responses induced by noradrenaline and serotonin.

引用

页码：495 / 499

页数：5