PODOPHYLLOTOXIN ANALOGS .1. SYNTHESIS AND BIOLOGICAL EVALUATION OF CERTAIN TRANS-2-ARYL-TRANS-6-HYDROXYMETHYL-3-CYCLOHEXENECARBOXYLIC ACID GAMMA-LACTONES AS ANTIMITOTIC AGENTS

被引：26

作者：

SMISSMAN, EE

MURRAY, RJ

MCCHESNEY, JD

HOUSTON, LL

PAZDERNIK, TL

机构：

[1] UNIV KANSAS, SCH PHARM, DEPT MED CHEM, LAWRENCE, KS 66045 USA

[2] UNIV KANSAS, DEPT BIOCHEM, LAWRENCE, KS 66045 USA

[3] UNIV KANSAS, SCH MED, DEPT PHARMACOL, KANSAS CITY, KS 66103 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1976年 / 19卷 / 01期

关键词：

D O I：

10.1021/jm00223a025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：148 / 153

页数：6

共 43 条

[1]

AKAHORI A, 1972, CHEM PHARM BULL, V20, P1150, DOI 10.1248/cpb.20.1150

[2] The arylbutadiene-maleic anhydride reaction [J].

Arnold, RT ;

Coyner, EC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1944, 66 :1542-1545

[3] DESOXYPODOPHYLLOTOXIN, CYTOTOXIC PRINCIPLE OF CALLITRIS-COLUMELLARIS F-MUELL [J].

AYNEHCHI, Y .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (01) :121-&

[4] REDUCTION OF CYCLIC ANHYDRIDES WITH NABH4 - VERSATILE LACTONE SYNTHESIS [J].

BAILEY, DM ;

JOHNSON, RE .

JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (10) :3574-&

[5]

BELKIN M, 1947, FED PROC, V6, P308

[6] ANTITUMOR AGENTS FROM BURSERA MICROPHYLLA (BURSERACEAE) .I. ISOLATION AND CHARACTERIZATION OF DEOXYPODOPHYLLOTOXIN [J].

BIANCHI, E ;

CALDWELL, ME ;

COLE, JR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (04) :696-&

[7] CONTROL OF LITHIUM ALUMINUM HYDRIDE REDUCTION OF CYCLIC DICARBOXYLIC ACID ANHYDRIDES TO PRODUCE GAMMA-LACTONES OR DIOLS [J].

BLOOMFIELD, JJ ;

LEE, SL .

JOURNAL OF ORGANIC CHEMISTRY, 1967, 32 (12) :3919-+

[8] RAPID METHOD FOR QUANTITATIVE DETERMINATION OF MICROTUBULE PROTEIN USING DEAE-CELLULOSE FILTERS [J].

BORISY, GG .

ANALYTICAL BIOCHEMISTRY, 1972, 50 (02) :373-&

[9] THE CHEMOTHERAPY OF CANCER .3. THE SYNTHESIS OF DIHYDROXYTETRAHYDRONAPHTHOIC ACIDS RELATED TO PODOPHYLLOTOXIN [J].

CAMPBELL, KN ;

CELLA, JA ;

CAMPBELL, BK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (19) :4681-4684

[10] HUMAN ANTICANCER EFFECT OF PODOPHYLLUM DERIVATIVES (SPG AND SPI) - A PRELIMINARY REPORT [J].

CHAKRAVORTY, RC ;

SARKAR, SK ;

SEN, S ;

MUKERJI, B .

BRITISH JOURNAL OF CANCER, 1967, 21 (01) :33-+

← 1 2 3 4 5 →