ANALYSIS OF CARBAMAZEPINE IN SERUM BY LIQUID-CHROMATOGRAPHY WITH DIRECT SAMPLE INJECTION AND SURFACTANT-CONTAINING ELUENTS

被引：11

作者：

BENTROP, D ^{[1
]}

WARREN, FV ^{[1
]}

SCHMITZ, S ^{[1
]}

BIDLINGMEYER, BA ^{[1
]}

机构：

[1] WATERS CHROMATOG,DIV MILLIPORE CORP,34 MAPLE ST,MILFORD,MA 01757

来源：

JOURNAL OF CHROMATOGRAPHY | 1990年 / 535卷 / 1-2期

关键词：

D O I：

10.1016/S0021-9673(01)88955-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Surfactant-containing eluents are evaluated for the analysis of carbamazepine in serum with conventional reversed-phase columns. Bovine serum was quantitatively eluted at the column void volume using surfactant concentrations in conventional reversed-phase eluents. The effect of pH, guard columns and column switching was evaluated with respect to separating and detecting clinical levels of the drug and its primary metabolite. Column lifetime was also investigated.

引用

页码：293 / 304

页数：12

共 16 条

[1] DETERMINATION OF ANTIBIOTICS AND ANTIMICROBIAL AGENTS IN HUMAN-SERUM BY DIRECT INJECTION ONTO SILICA LIQUID-CHROMATOGRAPHIC COLUMNS [J].

ADAMOVICS, JA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1987, 5 (03) :267-274

[2] PROCEDURES FOR DIRECT INJECTIONS OF UNTREATED BLOOD-PLASMA INTO LIQUID-CHROMATOGRAPHIC COLUMNS WITH EMPHASIS ON A PRE-COLUMN VENTING TECHNIQUE [J].

ARVIDSSON, T ;

WAHLUND, KG ;

DAOUD, N .

JOURNAL OF CHROMATOGRAPHY, 1984, 317 (DEC) :213-226

[3] SEPARATION OF IONIC COMPOUNDS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - AN UPDATE OF ION-PAIRING TECHNIQUES [J].

BIDLINGMEYER, BA .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1980, 18 (10) :525-539

[4]

BOWERS LD, COMMUNICATION

[5]

DESILETS CP, 1988, 12TH INT S COL LIQ C

[6] SHIELDED HYDROPHOBIC PHASE - A NEW CONCEPT FOR DIRECT INJECTION-ANALYSIS OF BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

GISCH, DJ ;

HUNTER, BT ;

FEIBUSH, B .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 433 :264-268

[7]

GROHS RA, IN PRESS ANAL CHEM

[8] INTERNAL-SURFACE REVERSED-PHASE SILICA SUPPORT FOR DIRECT INJECTION DETERMINATION OF DRUGS IN BIOLOGICAL-FLUIDS BY LIQUID-CHROMATOGRAPHY [J].

HAGINAKA, J ;

YASUDA, N ;

WAKAI, J ;

MATSUNAGA, H ;

YASUDA, H ;

KIMURA, Y .

ANALYTICAL CHEMISTRY, 1989, 61 (21) :2445-2448

[9] SOLID-PHASE EXTRACTION OF CARBAMAZEPINE AND 2 MAJOR METABOLITES FROM PLASMA FOR ANALYSIS BY HPLC [J].

HARTLEY, R ;

LUCOCK, M ;

FORSYTHE, WI ;

SMITHELLS, RW .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1987, 10 (11) :2393-2409

[10] DIRECT INJECTION OF UNTREATED SERUM USING NONIONIC AND IONIC MICELLAR LIQUID-CHROMATOGRAPHY FOR DETERMINATION OF DRUGS [J].

LOVE, LJC ;

ZIBAS, S ;

NOROSKI, J ;

ARUNYANART, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1985, 3 (06) :511-521

← 1 2 →