TANNINS AS SELECTIVE INHIBITORS OF PROTEIN-KINASE-C

被引：32

作者：

KASHIWADA, Y

NONAKA, GI

NISHIOKA, I

BALLAS, LM

JIANG, JB

JANZEN, WP

LEE, KH

机构：

[1] SPHINX PHARMACEUT CORP,DURHAM,NC 27717

[2] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)81072-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fifty-six tannins were evaluated for their inhibitory effects against protein kinase C (PKC). Ellagitannins and complex tannins were found to be potent inhibitors of PKC, while gallotannins and condensed tannins, having a relatively large number of phenolic hydroxy groups, showed moderate inhibitory effects on PKC. Phorbol displacement assay suggested that the active tannins interact with the regulatory site of the enzyme.

引用

页码：239 / 244

页数：6

共 10 条

[1]

CUI CB, 1991, CHEM PHARM BULL, V39, P2179, DOI 10.1248/cpb.39.2179

[2] EFFECTS OF ACTIVATORS OF PROTEIN-KINASE C, INCLUDING BRYOSTATIN-1 AND BRYOSTATIN-2, ON THE GROWTH OF A549 HUMAN-LUNG CARCINOMA-CELLS [J].

DALE, IL ;

GESCHER, A .

INTERNATIONAL JOURNAL OF CANCER, 1989, 43 (01) :158-163

[3]

GESCHER A, 1989, ANTI-CANCER DRUG DES, V4, P93

[4]

KASHIWADA Y, 1986, CHEM PHARM BULL, V34, P4083

[5]

LEE KW, IN PRESS J AM CHEM S

[6]

NISHIZAWA M, 1982, J CHEM SOC P1, P2968

[7] STUDIES AND PERSPECTIVES OF PROTEIN-KINASE-C [J].

NISHIZUKA, Y .

SCIENCE, 1986, 233 (4761) :305-312

[8]

TANAKA T, 1985, J CHEM RES, P176

[9]

TANAKA T, 1985, J CHEM RES M, P2001

[10]

WEINSTEIN IB, 1988, CANCER RES, V48, P4135

← 1 →