A CASE OF SKIN HYPERPIGMENTATION DUE TO ALPHA-MSH HYPERSECRETION

被引：27

作者：

PEARS, JS

JUNG, RT

BARTLETT, W

BROWNING, MCK

KENICER, K

THODY, AJ

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT BIOCHEM MED,DUNDEE DD1 9SY,SCOTLAND

[2] UNIV DUNDEE,NINEWELLS HOSP & MED SCH,DEPT DERMATOL,DUNDEE DD1 9SY,SCOTLAND

[3] UNIV NEWCASTLE UPON TYNE,ROYAL VICTORIA INFIRM,DEPT DERMATOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1992年 / 126卷 / 03期

关键词：

D O I：

10.1111/j.1365-2133.1992.tb00660.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A case is presented of generalized skin hyperpigmentation due to alpha-MSH hypersecretion from the pituitary that was most marked in the light-exposed areas. The patient also had secondary adrenal dysfunction, peripheral lymphadenopathy, streptococcal glomerulonephritis and malabsorption. Analysis of this patient's alpha-MSH using high-pressure liquid chromatography (HPLC) showed a novel acetylation profile compared to normal individuals and to patients with Cushing's disease and Nelson's syndrome. Glucocorticoid replacement therapy resulted in suppression of alpha-MSH hypersecretion and complete resolution of the illness.

引用

页码：286 / 289

页数：4

共 20 条

[1]

BURCHILL S A, 1991, Journal of Dermatological Science, V2, P281, DOI 10.1016/0923-1811(91)90052-Y

[2] TYROSINASE SYNTHESIS IN DIFFERENT SKIN TYPES AND THE EFFECTS OF ALPHA-MELANOCYTE-STIMULATING HORMONE AND CYCLIC-AMP [J].