A PHOTOCHEMICALLY TRIGGERED DNA-CLEAVING AGENT - SYNTHESIS, MECHANISTIC AND DNA CLEAVAGE STUDIES ON A NEW ANALOG OF THE ANTITUMOR ANTIBIOTIC DYNEMICIN

被引：101

作者：

WENDER, PA

ZERCHER, CK

BECKHAM, S

HAUBOLD, EM

机构：

[1] Department of Chemistry, Stanford University, Stanford

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 22期

关键词：

D O I：

10.1021/jo00074a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved procedure for the fluoride-induced desilylative condensation of a silyl-protected alkyne with an aldehyde provides the first example of dynemicin analogs (11) that can be activated by photochemical deprotection on nitrogen, leading to DNA cleavage under neutral conditions in the absence of chemical activators.

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页码：5867 / 5869

页数：3

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