MULTIPLE GENES CODE FOR HIGH-MOLECULAR-MASS RHOPTRY PROTEINS OF PLASMODIUM-YOELII

被引：35

作者：

BORRE, MB ^{[1
]}

OWEN, CA ^{[1
]}

KEEN, JK ^{[1
]}

SINHA, KA ^{[1
]}

HOLDER, AA ^{[1
]}

机构：

[1] NATL INST MED RES,DIV PARASITOL,LONDON NW7 1AA,ENGLAND

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1995年 / 70卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

RHOPTRY PROTEIN; MULTIGENE FAMILY; PLASMODIUM YOELII; MALARIA;

D O I：

10.1016/0166-6851(95)00025-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the number of genes coding for a group of high-molecular-mass rhoptry protein(s) in the malaria parasite Plasmodium yoelii, and studied variation in the gene family within the parasite's genome. A region of the genes was amplified using oligonucleotides based on conserved DNA sequences and the products cloned. The sequences could be divided into 7 groups by restriction-fragment-length polymorphism. Further variation was detected by sequence analysis; 11 different sequences were detected in the 16 clones analyzed. The genes in the family were distributed on 6 chromosomes probably at 9 or more loci.

引用

页码：149 / 155

页数：7

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