CAAT ENHANCER BINDING-PROTEIN IS ABLE TO BIND TO ATF CRE ELEMENTS

被引:54
作者
BAKKER, O [1 ]
PARKER, MG [1 ]
机构
[1] IMPERIAL CANC RES FUND,MOLEC ENDOCRINOL LAB,LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND
关键词
D O I
10.1093/nar/19.6.1213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The transcription factor C/EBP is known to be able to bind to two different classes of sites, a CAAT-box and one present in a number of viral enhancers. In this paper we show using band-shift assays, methylation interference and footprinting that C/EBP is also able to bind with high affinity to ATF/CRE sites. Competition with mutant ATF sites and methylation interference indicate that C/EBP may be able to bind to the ATF/CRE sites by virtue of their homology to the enhancer core elements. Furthermore, we show that C/EBP is able to direct transcription from this site in transient transfection experiments and that mutations in the ATF binding site that impair DNA binding also effect the ability of C/EBP to stimulate transcription.
引用
收藏
页码:1213 / 1217
页数:5
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