ENZYMES IN ORGANIC-SYNTHESIS .2. ONE-POT SYNTHESIS OF TAGATOSE 1,6-BISPHOSPHATE BY DIASTEREOSELECTIVE ENZYMATIC ALDOL ADDITION

被引：40

作者：

FESSNER, WD

EYRISCH, O

机构：

[1] Institut Für Organische Chemie Und Biochemie, Universität Freiburg, D-W-7800

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 01期

关键词：

D O I：

10.1002/anie.199200561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new aldolase from E. coli, the D-tagatose-1,6-bisphosphate-aldolase (TagA), catalyzes the asymmetric addition of dihydroxyacetone phosphate to D-glycerinaldehyde-3-phosphate, which can be used for the efficient synthesis of the bisphosphate 1 of the rare carbohydrate metabolite D-tagatose. A 4-epimer formed as a byproduct in small amounts can be removed easily from the mixture of products by subsequent specific enzymatic reactions.

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页码：56 / 58

页数：3

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