SMOOTHING GROUPED BIVARIATE DATA TO OBTAIN THE INCUBATION PERIOD DISTRIBUTION OF AIDS

被引：4

作者：

TAYLOR, JMG

CHON, Y

机构：

[1] Department of Biostatistics, UCLA School of Public Health, Los Angeles, California

来源：

STATISTICS IN MEDICINE | 1994年 / 13卷 / 09期

关键词：

D O I：

10.1002/sim.4780130907

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We use a penalized likelihood approach to obtain a smooth estimate of a bivariate distribution from grouped data where each observation consists of a region in a plane. The purpose of the analysis is to estimate the incubation period distribution of AIDS from the Multicenter AIDS Cohort Study, a prevalent cohort of homosexual men. In this article we illustrate the usefulness of the penalized likelihood approach. We also discuss the use of a cross-validation and a Bayesian scheme to choose the smoothing parameters and bootstrap samples to assess uncertainty.

引用

页码：969 / 981

页数：13

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