GROWTH AND REGRESSION IN TADPOLE PANCREAS DURING SPONTANEOUS AND THYROID HORMONE-INDUCED METAMORPHOSIS

被引：6

作者：

Atkinson, Burr G. ^{[1
]}

Little, Gwynne H. ^{[1
]}

机构：

[1] Florida State Univ, Dept Chem, Tallahassee, FL 32306 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1972年 / 1卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0047-6374(72)90075-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Administration of thyroid hormone to stage X premetamorphic tadpoles results in many changes in the pancreas including a drastic weight loss, decreased protein concentration, increased free amino acid pool, and increased protein degradation and. DNA synthesis. DNA concentration remains constant, and evidence is 'presented which demonstrates that cellular necrosis is responsible for the decrease in pancreatic mass. These transitions induced by thyroid hormone parallel those which occur at stages XIX to XXII during normal metamorphosis. These studies also suggest that the thyroid hormone may have little or no role in the subsequent differentiation of the newly proliferated pancreatic cells.

引用

页码：299 / 312

页数：14

共 24 条

[1] Atkinson B., 1972, DEV BIOL, V29
[2] Atkinson B.G., 1971, P 7 C ENDOCRINOLOGY, P48
[3] Blacker A., 1936, BIOL ZENTRALBI, V50, P285
[4] Burton K, 1968, METHODS ENZYMOLOGY B, V12, P163
[5] Claybrook J. R., 1963, THESIS U TEXAS
[6] Eaton J., 1971, THESIS FLOR STAT U
[7] Etkin W., 1968, METAMORPHOSIS PROBLE, P313
[8] FOLCH J, 1957, J BIOL CHEM, V226, P497
[9] Frieden E., 1970, MECHANISMS HORMONE A, P1
[10] Feeding Experiments on tadpoles. I. The intlnence of specific organs given as food on growth and differentiation. A contribution to the knowledge of organs with internal secretion.
Gudernatsch, JF
[J]. ARCHIV FUR ENTWICKLUNGSMECHANIK DER ORGANISMEN, 1912, 35 (03): : 457 - 483

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