A DIVERSE SET OF DEVELOPMENTALLY REGULATED PROTEOGLYCANS IS EXPRESSED IN THE RAT CENTRAL-NERVOUS-SYSTEM

被引：248

作者：

HERNDON, ME ^{[1
]}

LANDER, AD ^{[1
]}

机构：

[1] MIT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA 02139

来源：

NEURON | 1990年 / 4卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0896-6273(90)90148-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cellular interactions in neural development are influenced by various extracellular proteins, many of which bind glycosaminoglycans or proteoglycans. Precise functions of nervous system proteoglycans remain unknown, in part because neural proteoglycan composition is poorly understood. In this study, 25 putative proteoglycan core proteins were identified in subcellular fractions of rat brain. Levels of many of these varied considerably during development. Membrane-associated proteoglycans included two heparan sulfate proteoglycans (cores of 50 and 59 kd) that are covalently linked to glycosyl-phosphatidylinositol lipid, as well as several that appear to aggregate either with themselves or with copurifying proteins. These data indicate that brain proteoglycans exhibit the abundance, structural diversity, and developmental regulation that would be anticipated for molecules with diverse developmental functions. © 1990.

引用

页码：949 / 961

页数：13

共 68 条

[1] IMMUNOCYTOCHEMICAL LOCALIZATION OF A CHONDROITIN SULFATE PROTEOGLYCAN IN NERVOUS-TISSUE .2. STUDIES IN DEVELOPING BRAIN [J].