REDUCTION OF OXOTREMORINE-INDUCED ANALGESIA AFTER CHRONIC BUT NOT ACUTE RESTRAINT STRESS

被引：3

作者：

BADIANI, A ^{[1
]}

PAVONE, F ^{[1
]}

机构：

[1] CNR, IST PSICOBIOL & PSICOFARMACOL, VIA RENO 1, I-00198 ROME, ITALY

来源：

PSYCHOPHARMACOLOGY | 1991年 / 104卷 / 01期

关键词：

STRESS; ANALGESIA; CHOLINERGIC SYSTEM; OXOTREMORINE; MICE;

D O I：

10.1007/BF02244554

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.

引用

页码：57 / 61

页数：5

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