GEOMETRY OF ADULT-RAT SENSORY NEURONS IN CULTURE - ITS MODULATION BY LAMININ

被引：11

作者：

ITOH, T

SOBUE, G

YASUDA, T

MITSUMA, T

TAKAHASHI, A

KIMATA, K

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROL,NAGOYA,AICHI 466,JAPAN

[2] DAGOYA DAINI RED CROSS HOSP,DEPT NEUROL,NAGOYA,JAPAN

[3] AICHI MED UNIV,INST MOLEC SCI MED,NAGAKUTE,AICHI 48011,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 123卷 / 02期

关键词：

ADULT DRG NEURON; LAMININ; NEURON CULTURE;

D O I：

10.1016/0304-3940(91)90933-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Geometrical analysis of highly-purified and low-density adult rat dorsal root ganglion (DRG) neuron culture proved that laminin enhanced the total neurite length and the maximal extension of neurites, but did not significantly increase the neurite branching nor soma size particularly after 4 days of culture. Survival rates of adult DRG neurons were not affected by laminin. These results suggest that laminin is a potent modulator of neurite geometry in adult rat DRG neurons, which promotes neurite elongation rather than neurite branching.

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页码：212 / 216

页数：5

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