ORTHOSIPHOL-A AND ORTHOSIPHOL-B, NOVEL DITERPENOID INHIBITORS OF TPA (12-O-TETRADECANOYLPHORBOL-13-ACETATE)-INDUCED INFLAMMATION, FROM ORTHOSIPHON-STAMINEUS

被引：60

作者：

MASUDA, T

MASUDA, K

SHIRAGAMI, S

JITOE, A

NAKATANI, N

机构：

[1] Laboratory of Food Chemistry, Faculty of Science of Living, Osaka City University, Osaka, 558, Sumiyoshi

来源：

TETRAHEDRON | 1992年 / 48卷 / 33期

关键词：

D O I：

10.1016/S0040-4020(01)89868-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel highly oxygenated pimarane diterpenes, orthosiphol A (1) and B (2), have been isolated from the dry leaves of Orthosiphon stamineus Benth (Labiatae). Their structures were elucidated by spectroscopic and chemical methods. Orthosiphol A and B showed potent inhibitory activity against the inflammation induced by a tumor promoter, TPA (12-O-tetradecanoylphorbol-13-acetate), on mouse ears

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页码：6787 / 6792

页数：6

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