A NEW STRATEGY FOR SOLID-PHASE SYNTHESIS OF O-GLYCOPEPTIDES

被引：52

作者：

BIELFELDT, T

PETERS, S

MELDAL, M

BOCK, K

PAULSEN, H

机构：

[1] UNIV HAMBURG,INST ORGAN CHEM,MARTIN LUTHER KING PL 6,W-2000 HAMBURG 13,GERMANY

[2] CARLSBERG LAB,DEPT CHEM,DK-2500 COPENHAGEN,DENMARK

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 07期

关键词：

D O I：

10.1002/anie.199208571

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By direct glycoside synthesis, activated glycosyl amino acids are accessible. They can be utilized in the solid-phase synthesis for the preparation of glycopeptides with 2-azido-2-deoxy-D-galactose residues. The transformation into the acetamido derivatives and the subsequent deblocking occur on the polymeric support. This method is quite powerful, as the synthesis of the pentaglycosidated octapeptide shown below proves.

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页码：857 / 859

页数：3

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