TOTAL SYNTHESIS OF DISCORHABDIN-C - A GENERAL AZA SPIRO DIENONE FORMATION FROM O-SILYLATED PHENOL DERIVATIVES USING A HYPERVALENT IODINE REAGENT

被引：187

作者：

KITA, Y

TOHMA, H

INAGAKI, M

HATANAKA, K

YAKURA, T

机构：

[1] Faculty of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1992年 / 114卷 / 06期

关键词：

D O I：

10.1021/ja00032a036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hypervalent iodine oxidation of O-silylated phenols bearing various types of aminoquinones at the para position in 2,2,2-trifluoroethanol gave azacarbocyclic spiro dienones in good yields. Using this method, the first total synthesis of discorhabdin C, which was isolated from the sponge of Latrunculia du Bocage in New Zealand, was achieved.

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页码：2175 / 2180

页数：6

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