APPROACHES TO THE DESIGN OF BIOCHEMICAL PROBES FOR POSITRON EMISSION TOMOGRAPHY

被引：8

作者：

BARRIO, JR

机构：

[1] LAB NUCL MED,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT PHARMACOL,LOS ANGELES,CA 90024

来源：

NEUROCHEMICAL RESEARCH | 1991年 / 16卷 / 09期

关键词：

POSITRON-EMITTERS; BIOCHEMICAL PROBES; FLUORINATED ANALOGS; POSITRON EMISSION TOMOGRAPHY; NEUROTRANSMITTER ENZYME PROBES;

D O I：

10.1007/BF00965849

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the development of the 2-deoxy-D-glucose procedure by L. Sokoloff considerable advances have been made in the design of radiotracers for estimation of in-vivo biochemical parameters. Many of these advances are due to the development of positron emission tomography. As a result key biochemical processes can now be evaluated with newly developed positron-emitting labeled enzyme probes in man, in-vivo, allowing the study of a wide range of specific cellular processes in health and disease states.

引用

页码：1047 / 1054

页数：8

共 72 条

[1]

ABELES RH, 1990, J BIOL CHEM, V265, P16705

[2]

[Anonymous], 1972, STRUCTURAL STABILITY

[3] TURNOVER OF BRAIN MONOAMINE-OXIDASE MEASURED INVIVO BY POSITRON EMISSION TOMOGRAPHY USING L-[C-11]DEPRENYL [J].