ASYMMETRIC-SYNTHESIS OF FUNCTIONALIZED PYRROLIDINES - HIGHLY DIASTEREOSELECTIVE CYCLIZATIONS MEDIATED BY SULFIDE AND SULFOXIDE LIGANDS

被引：37

作者：

DAVIES, IW

GALLAGHER, T

LAMONT, RB

SCOPES, DIC

机构：

[1] GLAXO GRP RES LTD,DEPT STRUCT CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

[2] GLAXO GRP RES LTD,DEPT MED CHEM,WARE SG12 0DP,HERTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 04期

关键词：

D O I：

10.1039/c39920000335

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Silver(i)-catalysed cyclisation of sulfide 1b and sulfoxides 4 and 5 to give the corresponding 2-vinylpyrrolidines 2b, 6a and 7a, respectively proceeds with a high (up to 99% diastereoisomeric excess) level of diastereoselectivity; in all of these cases the sense of asymmetric induction observed has been shown to be the same.

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页码：335 / 337

页数：3

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