DEVELOPMENTAL EXPRESSION OF VOLTAGE-SENSITIVE K+ CHANNELS IN MOUSE SKELETAL-MUSCLE AND C2C12 CELLS

被引：52

作者：

LESAGE, F

ATTALI, B

LAZDUNSKI, M

BARHANIN, J

机构：

[1] Institut de Pharmacologie Moléculaire et Cellulaire, 660 route des Lucioles, Sophia Antipolis

来源：

FEBS LETTERS | 1992年 / 310卷 / 02期

关键词：

IONIC CHANNEL; MYOBLAST; MYOTUBE; DIFFERENTIATION; DEVELOPMENT;

D O I：

10.1016/0014-5793(92)81320-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The developmental expression of voltage-sensitive K+ channels was analyzed by Northern blot in mouse skeletal muscle. Of nine Shaker-like genes studied, eight are expressed in this mammalian muscle. Their expression is differentially regulated during development. The mouse cell line C2C12 has been used to study expression of voltage-sensitive K+ channels during in vitro myotube differentiation. Different voltage-sensitive K+ channel messages are also expressed in these cells which display a pattern of expression depending upon the differentiation stage. The message for the very peculiar K+ channel of IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA.

引用

页码：162 / 166

页数：5

共 29 条

[1]

ATTALI B, 1992, J BIOL CHEM, V267, P8650

[2] MEMBERS OF THE RCK POTASSIUM CHANNEL FAMILY ARE DIFFERENTIALLY EXPRESSED IN THE RAT NERVOUS-SYSTEM [J].