IMBALANCE OF THE G(S) AND G(I/O) FUNCTION IN POSTMORTEM HUMAN BRAIN OF DEPRESSED-PATIENTS

被引：42

作者：

OZAWA, H ^{[1
]}

GSELL, W ^{[1
]}

FROLICH, L ^{[1
]}

ZOCHLING, R ^{[1
]}

PANTUCEK, F ^{[1
]}

BECKMANN, H ^{[1
]}

RIEDERER, P ^{[1
]}

机构：

[1] UNIV WURZBURG,DEPT PSYCHIAT,W-8700 WURZBURG,GERMANY

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1993年 / 94卷 / 01期

关键词：

DEPRESSION; GTP BINDING PROTEIN; HUMAN BRAIN; PHOTOAFFINITY LABELING; SIGNAL TRANSDUCTION;

D O I：

10.1007/BF01244984

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The amounts of various G protein subunits in postmortem brain samples from the parietal and temporal cortices were the same in controls and depressive patients as demonstrated by immunoblotting. However, photoaffinity GTP labeling (AAGTP) of G(i/o)alpha but not G(s)alpha was significantly increased in depressives in both cortex regions. Furthermore, the ratio of G(a)/G(i/o) AAGTP incorporation revealed a significant reduction in depressives in these regions. The present findings suggest that an imbalance of second messengers via G protein function may be involved in the pathophysiology of depression.

引用

页码：63 / 69

页数：7

共 18 条

[1] THE INVOLVEMENT OF GUANINE-NUCLEOTIDE BINDING-PROTEINS IN THE PATHOGENESIS AND TREATMENT OF AFFECTIVE-DISORDERS [J].