ALTERATION OF CORTICAL AND HIPPOCAMPAL CHOLINERGIC ACTIVITIES FOLLOWING LESION OF THE MAMMILLARY BODIES IN MICE

被引:8
作者
BERACOCHEA, DJ
MICHEAU, J
JAFFARD, R
机构
[1] Laboratoire de Neurosciences Cognitives et Comportementales, URA CNRS 339, 33405 Talence Cedex, Universitede Bordeaux 1, Ave. des Facultes
关键词
ACETYLCHOLINE; HIGH AFFINITY CHOLINE UPTAKE; DIENCEPHALIC AMNESIA; HIPPOCAMPUS; CORTEX;
D O I
10.1016/0006-8993(94)01253-E
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of ibotenic acid lesions of the mammillary bodies (MM) on the sodium-dependent high affinity choline uptake (SDHACU) velocity into both the hippocampus and the frontal cortex were investigated in this study in either a quiet or an active (exploration of a T-maze) condition. Results showed that MM lesion globally produced a significant decrease of both hippocampal and cortical SDHACU. However, the magnitude of this decrease was not significantly different in the active as compared to the quiet condition. These findings suggest that MM lesion alters the tonically but not phasically active transynaptic control of cortical and hippocampal cholinergic activities.
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页码:53 / 58
页数:6
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