INHIBITION OF SATIETY BY A CHOLECYSTOKININ ANTAGONIST IS INDEPENDENT OF GASTRIC-EMPTYING

被引：6

作者：

COLLINS, SM

WEINGARTEN, HP

机构：

[1] MCMASTER UNIV, MED CTR, DEPT MED, INTESTINAL DIS RES UNIT, HAMILTON L8N 3Z5, ONTARIO, CANADA

[2] MCMASTER UNIV, DEPT PSYCHOL, HAMILTON L8N 3Z5, ONTARIO, CANADA

来源：

PEPTIDES | 1984年 / 5卷 / 03期

关键词：

D O I：

10.1016/0196-9781(84)90073-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of the cholecystokinin antagonist proglumide to inhibit satiety induced by i.p. injections of cholecystokinin octapeptide (CCK-OP) and bombesin was examined in rats equipped with chronic gastric annulae. Both CCK-OP and bombesin significantly suppressed sham feeding. Proglumide administered alone did not alter sham feeding but it abolished the suppression of feeding induced by CCK-OP. Proglumide did not inhibit the effect of a low dose of bombesin, but partially inhibited satiety induced by a high dose of bombesin, thus confirming previous findings. The effect of proglumide is evidently independent of its recently described effects on gastric emptying in rat.

引用

页码：481 / 484

页数：4

共 16 条

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