STRUCTURAL PLASTICITY BROADENS THE SPECIFICITY OF AN ENGINEERED PROTEASE

被引：155

作者：

BONE, R ^{[1
]}

SILEN, JL ^{[1
]}

AGARD, DA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

来源：

NATURE | 1989年 / 339卷 / 6221期

关键词：

D O I：

10.1038/339191a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：191 / 195

页数：5

共 27 条

[1] CATALYTIC MECHANISM OF SERINE PROTEASES - RE-EXAMINATION OF THE PH-DEPENDENCE OF THE HISTIDYL 1J13C2-H COUPLING-CONSTANT IN THE CATALYTIC TRIAD OF ALPHA-LYTIC PROTEASE
BACHOVCHIN, WW
KAISER, R
RICHARDS, JH
ROBERTS, JD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12): : 7323 - 7326
[2] ACTIVE-SITE OF ALPHA-LYTIC PROTEASE - ENZYME-SUBSTRATE INTERACTIONS
BAUER, CA
BRAYER, GD
SIELECKI, AR
JAMES, MNG
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1981, 120 (02): : 289 - 294
[3] SERINE PROTEASE MECHANISM - STRUCTURE OF AN INHIBITORY COMPLEX OF ALPHA-LYTIC PROTEASE AND A TIGHTLY BOUND PEPTIDE BORONIC ACID
BONE, R
SHENVI, AB
KETTNER, CA
AGARD, DA
[J]. BIOCHEMISTRY, 1987, 26 (24) : 7609 - 7614
[4] BONE R, IN PRESS BIOCHEMISTR
[5] MOLECULAR-STRUCTURE OF THE ALPHA-LYTIC PROTEASE FROM MYXOBACTER-495 AT 2-8-A RESOLUTION
BRAYER, GD
DELBAERE, LTJ
JAMES, MNG
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1979, 131 (04) : 743 - 775
[6] ANALYTICAL MOLECULAR-SURFACE CALCULATION
CONNOLLY, ML
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1983, 16 (OCT) : 548 - 558
[7] SOLVENT-ACCESSIBLE SURFACES OF PROTEINS AND NUCLEIC-ACIDS
CONNOLLY, ML
[J]. SCIENCE, 1983, 221 (4612) : 709 - 713
[8] REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY
CRAIK, CS
LARGMAN, C
FLETCHER, T
ROCZNIAK, S
BARR, PJ
FLETTERICK, R
RUTTER, WJ
[J]. SCIENCE, 1985, 228 (4697) : 291 - 297
[9] ROLE OF ARGININE-292 IN THE SUBSTRATE-SPECIFICITY OF ASPARTATE-AMINOTRANSFERASE AS EXAMINED BY SITE-DIRECTED MUTAGENESIS
CRONIN, CN
KIRSCH, JF
[J]. BIOCHEMISTRY, 1988, 27 (12) : 4572 - 4579
[10] INFLUENCE OF GEOMETRIC PROPERTIES OF ACTIVE CENTER ON SPECIFICITY OF ALPHA-CHYMOTRYPSIN CATALYSIS
DOROVSKA, VN
MARTINEK, K
KAZANSKA.NF
KLYOSOV, AA
VARFOLOM.SD
[J]. FEBS LETTERS, 1972, 23 (01) : 122 - &

← 1 2 3 →