HUMAN TRYPANOSOMIASIS IN THE IVORY-COAST - THERAPY AND PROBLEMS

被引:42
作者
DOUA, F
YAPO, FB
机构
[1] Projet de Recherches Cliniques sur la Trypanosomiase (PRCT), Daloa
[2] Service de Neurologie, Centre Hospitalier Universitaire (CHU) de Cocody
关键词
HUMAN AFRICAN TRYPANOSOMIASIS; AFRICA; TRYPANOSOMIASIS; IVORY COAST; PENTAMIDINE; MELARSOPROL; DFMO;
D O I
10.1016/0001-706X(93)90090-X
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Human African trypanosomiasis (sleeping sickness) caused by Trypanosoma gambiense is recrudescing alarmingly in the Ivory Coast. Between 1987 and 1992, 980 new cases were registered. In the Bouafle District alone, 214 new cases were diagnosed in 1992, with a prevalence reaching 7% in some villages. This situation is a consequence of the neglect of control activities over the last five years. The problems linked with treatment of sleeping sickness in 626 patients, using three drugs, are described. The side-effects vary in severity according to the drug used. Out of 350 patients treated with melarsoprol (ARSOBAL), 4% developed encephalopathy, 5.7% died during treatment, 2% of encephalopathy. Relapses were noted in 3.7% of patients between 3 and 20 months after treatment. Among 150 patients treated with pentamidine, one case of diabetes mellitus was observed. The patient died of this complication 24 months after treatment. 2% relapses or reinfections were registered after pentamidine treatment. The most frequently encountered side-effects during intravenous plus oral treatment with DFMO were diarrhoea (64.4%) and anemia (35.5%). This drug was just as effective and better tolerated when treatment was limited to 14 days and administered intravenously only.
引用
收藏
页码:163 / 168
页数:6
相关论文
共 18 条
[1]  
Aiyedun B A, 1976, Acta Trop, V33, P96
[2]   PENTAMIDINE CONCENTRATIONS IN PLASMA, WHOLE-BLOOD AND CEREBROSPINAL-FLUID DURING TREATMENT OF TRYPANOSOMA-GAMBIENSE INFECTION IN COTE-DIVOIRE [J].
BRONNER, U ;
DOUA, F ;
ERICSSON, O ;
GUSTAFSSON, LL ;
MIEZAN, TW ;
RAIS, M ;
ROMBO, L .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) :608-611
[3]   TREATMENT OF HUMAN LATE STAGE GAMBIENSE TRYPANOSOMIASIS WITH ALPHA-DIFLUOROMETHYLORNITHINE (EFLORNITHINE) - EFFICACY AND TOLERANCE IN 14 CASES IN COTE-DIVOIRE [J].
DOUA, F ;
BOA, FY ;
SCHECHTER, PJ ;
MIEZAN, TW ;
DIAI, D ;
SANON, SR ;
DERAADT, P ;
HAEGELE, KD ;
SJOERDSMA, A ;
KONIAN, K .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1987, 37 (03) :525-533
[4]  
DUMAS M, 1976, MED AFR NOIRE, V232, P39
[5]  
Ginoux P Y, 1984, Med Trop (Mars), V44, P149
[6]  
Ginoux P Y, 1984, Med Trop (Mars), V44, P351
[7]  
MAES L, 1988, ANN SOC BELG MED TR, V68, P219
[8]  
NKANGA NG, 1988, MED AFRIQUE NOIRE, V35, P73
[9]   TRIAL OF PREDNISOLONE FOR PREVENTION OF MELARSOPROL-INDUCED ENCEPHALOPATHY IN GAMBIENSE SLEEPING SICKNESS [J].
PEPIN, J ;
GUERN, C ;
ETHIER, L ;
MILORD, F ;
MPIA, B ;
MANSINSA, D .
LANCET, 1989, 1 (8649) :1246-1250
[10]   AFRICAN TRYPANOSOMIASIS AND DRUG-INDUCED ENCEPHALOPATHY - RISK-FACTORS AND PATHOGENESIS [J].
PEPIN, J ;
MILORD, F .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (02) :222-224