SUBOPTIMAL RESPONSE FOLLOWING INTRADERMAL HEPATITIS-B VACCINE IN INFANTS

被引:11
作者
COBERLY, JS
TOWNSEND, T
REPKE, J
FIELDS, H
MARGOLIS, H
HALSEY, NA
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT OBSTET & GYNECOL,BALTIMORE,MD 21205
[3] CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL DIS,HEPATITIS BRANCH,ATLANTA,GA 30333
关键词
HEPATITIS B VACCINE; INFANTS; RESPONSE;
D O I
10.1016/0264-410X(94)90332-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Two hundred and twenty-five infants were randomly assigned to receive 2 mu g of plasma-derived hepatitis B vaccine (Heptavax) intradermally (ID-2), 10 mu g intramuscularly (IM-10), or 2 mu g intramuscularly (IM-2) in the deltoid region at birth, 2 and 4 months. At 6 months, ID-2 infants were less likely to have developed greater than or equal to 10 mIU ml(-1) of antibody to hepatitis B surface antigen (anti-HBs) than IM-10 infants (91 versus 100%; p=0.02) and had a lower geometric mean concentration of anti-HBs (312 mIU ml(-1) versus 2248 mIU ml(-1); p<0.01). At 6 months IM-10 infants had significantly lower mean weights and lengths than infants receiving 2 mu g doses of vaccine. Intramuscular administration of 2 mu g and 10 mu g doses of Heptavax in the deltoid of young infants was well tolerated and effective; however, intradermal administration of Heptavax provided no immunological benefit over intramuscular administration and resulted in significantly higher rates of induration and persistent hyperpigmentation. Intramuscular immunization at birth, 2 and 4 months is an acceptable, effective alternative schedule for immunizing infants.
引用
收藏
页码:984 / 987
页数:4
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