SYNTHESIS OF A CYCLITOL VIA A TANDEM ENZYMATIC ALDOL - INTRAMOLECULAR HORNER-WADSWORTH-EMMONS REACTION

被引：21

作者：

GIJSEN, HJM ^{[1
]}

WONG, CH ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 39期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01483-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aldol condensation between a phosphonate aldehyde and dihydroxyacetone phosphate catalyzed by fructose 1,6-diphosphate aldolase (EC 4.1.2.13) gives a product which in situ cyclizes via an intramolecular Horner-Wadsworth-Emmans (HWE) olefination to afford a polyhydroxylated cyclopentene. In this one-pot reaction, the HWE reaction takes place in aqueous solution at slightly acidic (pH 6.1-6.8) conditions.

引用

收藏

页码：7057 / 7060

页数：4

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