HOW CAN THE PRODUCTS OF A SINGLE-GENE BE LOCALIZED TO MORE THAN ONE INTRACELLULAR COMPARTMENT

被引：141

作者：

DANPURE, CJ

机构：

[1] MRC Protein Translocation Group, the Dept of Biology, University College London, London, WC1E 6BT, Gower Street

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 06期

关键词：

D O I：

10.1016/S0962-8924(00)89016-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein-targeting sequences are specific for each intracellular compartment, so that most proteins are found at only one location within the eukaryotic cell. Increasingly, however, examples are being found of proteins that occur and function in more than one cellular compartment. In some cases, the multicompartmentalized isoforms are encoded by the same gene. Several mechanisms have evolved to enable such genes to encode and differentially express multiple types of topogenic information. These mechanisms include alternative forms of transcription initiation, translation initiation, splicing and post-translational modification.

引用

页码：230 / 238

页数：9

共 78 条

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