Conflict of interest in psychiatry

被引：16

作者：

Ahmer, Syed ^{[1
]}

Arya, Pradeep ^{[2
]}

Anderson, Duncan ^{[3
]}

Faruqui, Rafey ^{[4
,5
]}

机构：

[1] Tony HillisWing West London Mental Hlth NHS Trust, Gen Adult Psychiat, Uxbridge Rd, Southall UB1 3EU, Middx, England

[2] St Charles Hosp, St Marys Higher Training Scheme Psychiat, Gen Adult Psychiat, Jefferson, NY 11777 USA

[3] West London Mental Hlth NHS Trust, Bridges Medium Secure Unit 3, Forens Psychiat, Southall, Middx, England

[4] West London Mental Hlth NHS Trust, Gen Adult Psychiat, Southall, Middx, England

[5] Imperial Coll London, London, England

来源：

PSYCHIATRIC BULLETIN | 2005年 / 29卷 / 08期

关键词：

D O I：

10.1192/pb.29.8.302

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

AIMS AND METHOD To study the association between study support and outcome in randomised controlled trials (RCTs) of psychotropic drugs, we reviewed all RCTs published in four psychiatry journals over a 5-year period. Chi-squared tests were used to analyse the association between RCT support and outcome, and logistic regression to determine which variable best predicted outcome. RESULTS A significantly higher proportion of manufacturer-supported RCTs (125/138, 91%, 95% CI 88-93) had a positive outcome than non-manufacturer-supported RCTs (39/50, 78%, 95% CI 72-84; P=0.02). Having an employee author almost guaranteed a positive outcome (56/58, 97%, 95% CI 94-99). CLINICAL IMPLICATIONS Outcomes of drug RCTs have a significant association with support by the manufacturer of the experimental drug. Systematic reviews and meta-analyses based on these RCTs may be biased in favour of newer drugs.

引用

页码：302 / 304

页数：3

共 20 条

[1]

[Anonymous], 2001, BMJ-BRIT MED J, V323, P651

[2] Influences on the quality of published drug studies [J].