A critical kinase cascade in neurological disorders: PI3K, Akt and mTOR

被引：95

作者：

Chong, Zhao Zhong ^{[1
,2
]}

Shang, Yan Chen ^{[1
,2
]}

Wang, Shaohui ^{[1
,2
]}

Maiese, Kenneth ^{[1
,2
,3
]}

机构：

[1] New Jersey Hlth Sci Univ, Lab Cellular & Mol Signaling, Ctr Canc, F-1220,205 South Orange Ave, Newark, NJ 07101 USA

[2] New Jersey Hlth Sci Univ, Newark, NJ 07101 USA

[3] Canc Inst New Jersey, New Brunswick, NJ USA

来源：

FUTURE NEUROLOGY | 2012年 / 7卷 / 06期

关键词：

Akt; Alzheimer's disease; apoptosis; autophagy; Huntington's disease; mammalian target of rapamycin; mTOR; Parkinson's disease; PI3K; stroke; trauma;

D O I：

10.2217/FNL.12.72

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurodegenerative disorders lead to disability and death in a significant proportion of the world's population. However, many disorders of the nervous system remain with limited effective treatments. Kinase pathways in the nervous system that involve PI3K, Akt and mTOR offer exciting prospects for the understanding of neurodegenerative pathways and the development of new avenues of treatment. PI3K, Akt and mTOR pathways are vital cellular components that determine cell fate during acute and chronic disorders, such as Huntington's disease, Alzheimer's disease, Parkinson's disease, epilepsy, stroke and trauma. However, the elaborate relationship among these kinases and the variable control of apoptosis and autophagy can lead to unanticipated biological and clinical outcomes. Crucial for the successful translation of PI3K, Akt and mTOR into robust and safe clinical strategies will be the further elucidation of the complex roles that these kinase pathways hold in the nervous system.

引用

页码：733 / 748

页数：16

共 166 条

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