HPA AXIS RESPONSIVITY TO DEXAMETHASONE AND COGNITIVE IMPAIRMENT IN DEMENTIA

被引：36

作者：

GUREVICH, D ^{[1
]}

SIEGEL, B ^{[1
]}

DUMLAO, M ^{[1
]}

PERL, E ^{[1
]}

CHAITIN, P ^{[1
]}

BAGNE, C ^{[1
]}

OXENKRUG, G ^{[1
]}

机构：

[1] BROWN UNIV, COLL MED, DEPT PSYCHIAT & HUMAN BEHAV, PROVIDENCE, RI 02912 USA

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1990年 / 14卷 / 03期

关键词：

cognitive impairment; cortisol; dementia; dexametnasone; HPA responsivity index;

D O I：

10.1016/0278-5846(90)90018-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Animal and human studies suggest a possible relationship between dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and cognitive impairment. 2. In animals, prolonged exposure to high plasma cortisol levels causes irreversible hippocampal damage. 3. Abnormal cortisol plasma levels in response to dexametnasone challenge have been frequently observed in dementia of Alzheimer's type (DAT) patients. 4. The authors studied the relationship of responsivity of the HPA axis to cognitive impairment in 34 DAT patients drug free for at least 10 days. A decrease in HPA axis responsivity significantly correlated with greater cognitive impairment. © 1990.

引用

页码：297 / 308

页数：12

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