GC MS IDENTIFICATION OF AMINE SOLVENT CONDENSATION PRODUCTS FORMED DURING ANALYSIS OF DRUGS OF ABUSE

被引：12

作者：

CLARK, CR ^{[1
]}

DERUITER, J ^{[1
]}

NOGGLE, FT ^{[1
]}

机构：

[1] DEPT FORENS SCI,AUBURN,AL 36830

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1992年 / 30卷 / 10期

关键词：

D O I：

10.1093/chromsci/30.10.399

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of methanol or ethanol as the injection solvent for the gas chromatographic-mass spectral (GC-MS) analysis of low molecular weight amine drugs of abuse results in the formation of additional components in the sample. Primary amines, such as amphetamine, 3, 4-methylenedioxyamphet- amine, and phenethylamine, yield imines upon injection as methanol or ethanol solutions. In methanol, the ¡mine formed has a mass that is 12 mass units higher than the parent compound. In ethanol, the products formed have 26 additional mass units. Secondary amines appear to undergo méthylation under similar conditions with methanol as the injection solvent. These products are absent from the analysis of equivalent amine samples dissolved in chloroform. © Oxford University Press 1992.

引用

页码：399 / 404

页数：6

共 9 条

[1]

ANGELOS SA, 1990, J FORENSIC SCI, V35, P1297

[2]

BREWER LM, 1991, J FORENSIC SCI, V36, P697

[3]

NOGGLE FT, 1985, J ASSOC OFF ANA CHEM, V68, P1213

[4] GAS-CHROMATOGRAPHIC AND MASS-SPECTROMETRIC ANALYSIS OF SAMPLES FROM A CLANDESTINE LABORATORY INVOLVED IN THE SYNTHESIS OF ECSTACY FROM SASSAFRAS OIL [J].