CAPACITY OF LIPOPHILIC AUXILIARY SUBSTANCES TO GIVE SPHERES BY EXTRUSION-SPHERONIZATION

被引：11

作者：

EDIMO, A ^{[1
]}

LETERME, P ^{[1
]}

DENIS, J ^{[1
]}

TRAISNEL, M ^{[1
]}

GAYOT, AT ^{[1
]}

机构：

[1] GATTEFOSSE,ST PRIEST,FRANCE

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 07期

关键词：

D O I：

10.3109/03639049309062985

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The authors consider the preparation of spheroids by extrusion-spheronization with Precirol ato 5 and Gelucire 50/02. The material is a ram extruder and a cylinder extruder associated to a spheronizer. Spheroids are obtained by adding an auxiliary substance such as microcrystalline cellulose. A comparison of the results obtained on the two types of extruder allows a better understanding of the pressure/displacement profile and emphasizes the necessary qualities of the wet mass and extrudates.

引用

页码：827 / 842

页数：16

共 8 条

[1]

BRIQUET F, 1984, STP PHARM, V2, P986

[2] THE CHARACTERIZATION OF WET POWDER MASSES SUITABLE FOR EXTRUSION SPHERONIZATION [J].